Video: Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis
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Video: Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis
3.7K Views. Acetoacetic ester synthesis is a method to obtain ketones from alkyl halides and β-keto esters. The reaction occurs in the presence of an alkoxide base that abstracts the acidic proton of the β-keto esters. The step results in an enolate ion which is doubly stabilized. The enolate then reacts with an alkyl halide via the SN2 ...
Aug 29, 2023
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