The Chicago Cubs (22-15) host the San Francisco Giants (23-14) in the rubber match of a 3-game series Wednesday. First pitch from Wrigley Field is scheduled for 2:20 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Giants vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

The Giants scored nine runs in the top of the eleventh inning en route to a 14-5 victory over the National League Central leaders on Tuesday.

The Cubs (22-14) cashed in on the miscues thanks to a Nicky Lopez bases-loaded walk, Ian Happ’s sacrifice fly and Seiya Suzuki’s two-run single. They tallied six unearned runs in the victory off four Giants errors.