Oligonucleotide arrays (GeneChip, Affymetrix) composed of 7,070 human (HUM 6.8K) or 6,347 mouse (MUR 6K) genes and ESTs were used for hybridization according to the manufacturer's instructions.

At the 2025 ASCO Annual Meeting, Natera presented a pan-cancer study involving 392 patients and 2,600+ samples using Signatera Genome, a recently launched assay for clinical and research use.

These assays also detect only a limited select number of mutations, but they are less expensive and more sensitive than sequencing assays. The Affymetrix HIV GeneChip utilizes a silicon-glass chip ...

Instead, multigene panel–based sequencing with fewer genes (324-595 genes in currently available panels) and coding regions (0.8-2.4 Mb) is more often used to estimate TMB. 90,99-107 Panel ...

Tips for optimising and validating your multiplex qPCR assays Multiplex qPCR is a popular area of interest for many assay developers. Thanks to distinct reporter dyes, multiple reactions can be ...

Our interdisciplinary school is leading scientific exploration and engineering expertise in sustainability solutions, biomedical innovation and advanced materials. We address crucial issues like ...

In target-based drug discovery, quantification of target engagement is required to build structure–activity relationships and develop a potent clinical candidate. Target engagement data also provides ...

The LAMP assay specifically targets the H5 hemagglutinin gene of the avian influenza virus. This assay offers important advantages over traditional diagnostic methods, Kamel noted. It detects the ...