Background Patients with SLE experience distressing fibromyalgia-like symptoms of fatigue, widespread pain, mood disturbance, and brain fog that negatively impact quality of life and are challenging ...

Results 293 visits from 124 patients were included, 116 (93.5%) were women with a mean age at diagnosis of 35.2 (12.6) years. Mean CQR at baseline was 75.9 (13.6) and at the end of follow-up was 76.4 ...

Background Single-cell RNA-sequencing (scRNA-seq) has been recently applied in systemic lupus erythematosus (SLE) to define distinct cellular composition and transcriptional signatures, greatly ...

Objective This systematic review seeks to survey existing literature concerning systemic lupus erythematosus (SLE)-related thrombosis risk mechanisms within six pro-coagulable categories: ...

Objective Explore organ-specific SLE burden by assessing health-related quality of life (HRQoL) and fatigue changes associated with Safety of Estrogens in Lupus Erythematosus National ...

Background Autoimmune and inflammatory diseases such as systemic lupus erythematous (SLE) affect tissues throughout the body. Alterations to inflammatory cell metabolism are often cited as a ...

Background Chromatin accessibility (CA) is a critical epigenetic feature identifying genomic loci that actively participate in gene-regulating functions, such as transcription and DNA repair. In turn, ...

Background In 1979, the first ever DNA crystal that was solved led to the surprising discovery of the left-hand Z-DNA conformation This structure forms from the right-handed classical B-DNA by ...

Introduction The occurrence of systemic lupus erythematosus (SLE), an autoimmune disease, is rare in male. It is observed in only 10% of cases. Its clinical presentation is different, and the ...