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BMJ Evidence-Based Medicine

BMJ Evidence-Based Medicine (BMJ EBM) publishes original evidence-based research, insights and opinions on what matters for health care. We focus on the tools, methods, and concepts that are basic and ...
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High dose lisinopril was more effective than low dose for reducing combined mortality and cardiovascular events in congestive heart failure

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Children’s and caregivers’ participation in the development of paediatric core outcome sets: a cross-sectional analysis

Objectives This study aims to address the status of children’s and caregivers’ participation in the development of paediatric core outcome sets (COS). Methods We included all paediatric COS from a ...
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Theory and practice of Bayesian and frequentist frameworks for network meta-analysis

Network meta-analysis (NMA) is an increasingly popular statistical method of synthesising evidence to assess the comparative benefits and harms of multiple treatments in a single analysis. Several ...
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Shared decision-making as a method of care

Care happens in interaction between the patient and the clinician, in conversation where the patient and clinician uncover or develop a shared understanding of the problematic situation of the patient ...
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Incomplete reporting and spin in acupuncture randomised controlled trials: a cross-sectional meta-epidemiological study

3 The Affiliated Guangzhou Hospital of TCM of Guangzhou University of Chinese Medicine, Guangzhou, China 4 The Affiliated Brain Hospital, Guangzhou Medical University, Key Laboratory of Neurogenetics ...
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Should antidepressants be used for major depressive disorder?

Background Major depressive disorder is estimated by the WHO to affect more than 300 million people globally, making depression the leading cause of disability worldwide. Antidepressants are commonly ...
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EBHC pyramid 5.0 for accessing preappraised evidence and guidance

Correspondence to: Dr Brian S Alper, DynaMed, EBSCO Health, 10 Estes Street, Ipswich, MA 01938, USA; balper{at}ebsco.com Practising evidence-based healthcare (EBHC) is integrating the best research ...
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Mapping drug-class associations with sudden cardiac arrest in the outpatient setting: an exploratory population-based case-control analysis

Objectives To map the risk profile of drug classes at the population level by identifying associations between newly prescribed reimbursed drugs and sudden cardiac arrest (SCA), thereby providing a ...
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Efficacy of smartphone apps used alone or with traditional interventions for smoking cessation: a systematic review and meta-analysis

Objectives To assess the efficacy of smartphone apps for smoking cessation (SC) used alone or combined with traditional interventions, and to determine whether apps based on psychological-behavioural ...
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Framework for the synthesis of non-randomised studies and randomised controlled trials: a guidance on conducting a systematic review and meta-analysis for healthcare decision ...

Introduction: High-quality randomised controlled trials (RCTs) provide the most reliable evidence on the comparative efficacy of new medicines. However, non-randomised studies (NRS) are increasingly ...
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Using and distinguishing evidence from non-randomised studies of interventions

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