If the Colts win, then the Jaguars will have to defeat the Colts on the road next week to secure their playoff spot. And while that would certainly be on the table for the red-hot Jaguars, they could enter Week 17 with a bit more peace of mind if the 49ers give them a hand.

Jacksonville Jaguars tight end Brenton Strange speaks about his affinity for playing in front of the home crowd, despite road success.

The Denver Broncos lost 34-20 to the Jacksonville Jaguars in Week 16, and now pose the risk of not only losing the AFC's number 1 seed, but even the AFC West. It was a brutal loss for the Broncos, and it could wind up being a very costly one down the stretch. They control their own destiny, but they no longer have any wiggle room.

DENVER, CO - DECEMBER 21: Denver Broncos head coach Sean Payton and quarterback Bo Nix (10) have a word before a game between the Jacksonville Jaguars and the Denver Broncos at Empower Field at Mile High on December 21, 2025 in Denver, Colorado. | Dustin Bradford / Icon Sportswire / Imago

The Broncos lost a potential playoff preview against the Jaguars, but they can still win the AFC and get to the Super Bowl.

He was not playing football like he usually does when he’s there. But Travis Hunter was back in Colorado for his Jacksonville Jaguars’ massive Week 16 matchup with the Denver Broncos.

NFL Week 17 odds, picks, predictions, TV channel, streaming information for Sunday football game between Jacksonville Jaguars and Indianapolis Colts.

How will the Jacksonville Jaguars wrap up the 2025 regular season? A quick look at the seemingly playoff-bound Jaguars.

Tonight's Monday Night Football game is between the Indianapolis Colts and the San Francisco 49ers. According to ESPN's Michael DiRocco, if the 49ers defeat the Colts, the Jaguars clinch a playoff spot. The LA Chargers and the Buffalo Bills would clinch a playoff spot as well.