The Guardians and Orioles open a four-game homestand July 21 at Progressive Field. Follow along here for live updates and highlights.

Pregame analysis and predictions of the Baltimore Orioles vs. Cleveland Guardians MLB game to be played on July 21, 2025 on ESPN.

The Cleveland Guardians do not sound eager to change their nickname back to the "Indians" after President Donald Trump called for the franchise to go back to its previous moniker in a social media post over the weekend.

President Donald Trump has called for Washington's football team and Cleveland's baseball team to return to their previous names

The Cleveland Guardians are reportedly open to the idea of trading closer Emmanuel Clase and reliever Cade Smith ahead of the MLB trade deadline on July 31.

The 2025 MLB trade deadline is Thursday, July 31 at 6 p.m. ET, but there will be plenty of trade talk and transactions that take place beforehand. Here are trade rumors around the sport:

The Cleveland Guardians reportedly have a short list of players whom they aren't willing to trade before the deadline.

See all the player props bets with current odds for the MLB matchup between the Cleveland Guardians and Orioles on }{ day_of_week model.date }}, July

It's Monday, July 21 and the Orioles (44-54) are in Cleveland to take on the Guardians (48-50). Tomoyuki Sugano is slated to take the mound for Baltimore against Tanner Bibee for Cleveland. Cleveland and Baltimore are set for a four-game series that could push the Guardians above .