Forecasting protein evolution in terms of folding stability using state-of-the-art population genetics and substitution models is feasible in rugged fitness landscapes, whereas forecasting exact amino ...

Apple developed an alternative AI model to predict the 3D structure of proteins, and it shows promise. Here are the details.

Directed evolution, on the other hand ... General inverse folding models like ESM-IF1 and ProteinMPNN learn from millions of protein structures and sequences. They understand how different amino acids ...

A team from the University of Illinois has uncovered surprising evolutionary links between the genetic code and tiny protein ...

A team of researchers reconstructed long-extinct proteins of a UV protection system of cyanobacteria. The surprising result: the proteins were already compatible with each other when they first met.

Synthesizing new proteins – the building blocks of biological life – is a scientific field of immense potential, and a newly developed AI model promises to create instructions for new proteins way ...

A new platform combines rational protein design with continuous evolution to discover functional molecules more efficiently. In medicine and biotechnology, the ability to evolve proteins with new or ...

The amount of any given protein in a cell has to be controlled to keep its levels within a range required for healthy ...

Up to now, the evolutionary trajectory of the most prevalent CO2-fixing enzyme – Rubisco Form I, has been difficult to study. The Rubisco found in today’s plants and algae has 8 small subunits (SSU) ...

Aquaglyceroporin Aqp10, a protein channel for water and glycerol, selectively permeates urea and boric acid due to its unique ...