Intrinsically disordered proteins (IDP) are proteins that lack tertiary structure. They are now being recognized as biologically crucial in both healthy systems and the pathophysiology of various ...
Intrinsically disordered proteins (IDPs) can be challenging to identify and study due to their characteristic lack of structure. Bioinformatics techniques have been developed to predict whether a ...
Proteins containing disordered domains perform many important cellular functions. My lab currently has two main projects, one to dissect the role of tubulin's C-terminal tail in microtubule structure ...
The yeast prion protein Sup35NM is a self-propagating amyloid. Despite intense study, there is no consensus on the organization of monomers within Sup35NM fibrils. Some studies point to a β-helical ...
The international competition to predict the three-dimensional (3D) structures of 43 proteins, using computational tools, was intense. Of the 123 groups competing in the fourth Critical Assessment of ...
The prediction of protein structure with the use of artificial intelligence and machine learning (AI–ML) is poised to transform how and when three-dimensional (3D) biostructure information is used in ...
Visualization of the protein clumps associated with Huntington’s disease, determined by combining simulations and multiple complementary types of experiments. The figure shows the overall structure at ...
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