Membrane proteins are cellular gatekeepers involved in many processes of high biological importance. Solid-state NMR spectroscopy is a unique tool to study both the dynamics and structure of ...

Protein NMR spectroscopy provides an important complement to X-ray crystallography for structural genomics, ... NMR structure determinations rely on the nearly complete assignment of chemical ...

‘13C APSY-NMR for sequential assignment of intrinsically disordered proteins’ — Murrali MG, Schiavina M, Sainati V, Bermel W, Pierattelli R, Felli IC, Journal of Biomolecular NMR, 2018.

Proteins are central to many disciplines within the life sciences, not least protein-based pharmaceuticals. Changes in protein conformation, structure or interactions could have significant impact on ...

Another high-resolution method is nuclear magnetic resonance (NMR) spectroscopy, which can be used to characterize protein structure in liquids. However, this method is only practical when ...

In particular, Dr. Rosenbaum and his laboratory use protein engineering, X-ray crystallography, and NMR spectroscopy to study the structure and dynamics of molecules involved in hormone signaling ...

Including the Ensemble of Unstructured Conformations in the Analysis of Protein's Native State by High‐Pressure NMR Spectroscopy. Angewandte Chemie International Edition , 2024; DOI: 10.1002 ...

An example of one MAS NMR spectrum. This is used to identify atoms in the molecule and, ultimately, for calculating their 3-D structures.

NMR can identify different nuclei in a molecule and analyze large proteins and other large molecules using three dimensional (3-D) techniques. This instrument provides powerful information for the ...