The inimitable adaptability of MALDI-TOF/TOF systems enables tissue imaging of intact proteins, as well as of tryptic peptides brought about by on-tissue digestion. Although intact protein imaging can ...

We performed a microinjection of matrix on 97 neurons from layer V of the motor cortex of YFP transgenic mice for this study, with matrix spot size diameters in the range of 25–500 µm. Profile spectra ...

MALDI is the most powerful ion desorption technology for examining many diverse classes of analyte molecules from different types of samples. When MALDI spectra are gathered in a spatially orientated ...

Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) is a powerful analytical mass spectrometry technique that has generated numerous diagnostic and clinical applications, especially ...

Bruker Daltonics has announced the release of MALDI BioTyper™ system for the identification and classification of microorganisms using protein 'fingerprints' measured by MALDI-TOF mass spectrometry at ...

EGFR mutation and copy number, EGFR protein expression and KRAS mutation as predictors of outcome with erlotinib in bronchioloalveolar cell carcinoma (BAC): Results of a prospective phase II trial ...

If a picture is worth a thousand words, what is its value when drawn with chemical information? Mass spectrometric imaging paints pictures in which the mass-to-charge ratios of the ions provide the ...

To find out the molecular weight of a compound is the basic task for mass spectrometry. If this is done precisely, it is possible to determine the elemental composition. If there are isomers with ...

Detailed elucidation of protein structure and function typically requires removal of the protein from its in vivo environment. However, applying traditional and detergent-based protein extraction and ...

Single-cell MALDI mass spectrometry (MS) imaging resolution is currently limited by the size of laser spot diameter, matrix crystal size/homogeneity, displacement of analytes during matrix deposition, ...