CoinDesk2d
The Protocol: Can Based Rollups Solve Ethereum’s Layer-2 Problem?
In recent years, Ethereum has embraced a layer-2 scaling roadmap—a plan that encouraged the development of third-party ...
The EMBO Journal1d
Portimine A toxin causes skin inflammation through ZAKα-dependent NLRP1 inflammasome activation
In 2020-2021, a mysterious skin disease affected fishermen in Senegal. High levels of Portimine A toxin, produced by the ...
eLife4d
Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids
Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a ...
The EMBO Journal4d
Proteogenomic analysis reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer
Aneuploidy is frequent in cancer, but in vitro it triggers multiple cellular stresses and often delays proliferation. Through ...
eLife3d
Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice
This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...
newsroom.unfccc.int21h
The Clean Development Mechanism
The Clean Development Mechanism (CDM), defined in Article 12 of the Protocol, allows a country with an emission-reduction or emission-limitation commitment under the Kyoto Protocol (Annex B Party) to ...