The Knicks' Karl-Anthony Towns (thumb) is questionable for Friday's game against the Timberwolves, who will be without starter Donte DiVincenzo (toe).

It’ll represent the durable DiVincenzo’s first DNP of the season for the T’wolves and puts a damper on an anticipated matchup between offseason trade partners.

MINNEAPOLIS — Minnesota Timberwolves guard Donte DiVincenzo will be out indefinitely with a toe injury, the team announced Monday.

DiVincenzo has a Grade 3 sprain in his left big toe after suffering the injury against the Golden State Warriors last week.

Karl-Anthony Towns likely is the player the Knicks can least do without, especially with Mitchell Robinson still unable to practice.

Knicks center Karl-Anthony Towns is questionable to face his former team Friday with a sprained right thumb, while Minnesota’s Donte DiVincenzo will miss his return to Madison Square Garden with a toe injury.

Just as Donte DiVincenzo was heating up, the injury bug bites. The Minnesota Timberwolves guard is out indefinitely due to a left big toe injury he sustained on Jan. 15 against Golden State, ESPN reported Monday. DiVincenzo, whose foot has been placed in a boot, will receive additional opinions on treatment options in the coming days.

DiVincenzo is undoubtedly bummed to miss Friday's game against his old team. It would've been his first regular season game at MSG since being traded from the Knicks to the Wolves along with Julius Randle in late September.

DiVincenzo was recently promoted to the starting lineup over Mike Conley and was averaging 17.5 points and 4.7 assists as a starter. Minnesota was 4-2 in those games.

Timberwolves guard Donte DiVincenzo is out indefinitely due to left big toe injury and will receive additional opinion, sources tell ESPN. DiVincenzo’s foot has been placed in a boot. He was averaging 17.5 points, 4.7 assists, 42% shooting on 3s as a starter in last 6 games. pic.twitter.com/Cb7QPa5MME

MEMPHIS — Donte DiVincenzo, who recently moved into the Minnesota Timberwolves starting lineup, is out indefinitely with a big toe injury, the team announced before Monday’s game against the Memphis Grizzlies. DiVincenzo, a 6-foot-4 guard in his seventh season out of Villanova, had missed the last two games with the injury.

Donte DiVincenzo, who recently moved into the Minnesota Timberwolves starting lineup, is out indefinitely with a big toe injury.