Gut

Engineered virus-hunter vaccine overcomes HBV immune tolerance

Background Globally, an estimated 296 million individuals live with chronic hepatitis B virus (HBV) infection, carrying ...
Gut

Gut microbiome in IBD: past, present and the future

IBD has become a global disease in the 21st century that shifts through four epidemiological stages. Alterations in the gut ...
Gut

Thrombospondin-2: a promising but unproven biomarker for MASH

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disorder worldwide, reflecting the growing prevalence of obesity and type 2 diabetes. Some patients ...
gut.bmj

Spatial single-cell omics in liver studies: cautions on metanarrative pitfalls

We read with great interest the review by Suo et al published in Gut recently, ‘Spatial single-cell omics: new insights into liver diseases’.1 This very well-written and comprehensive review ...
gut.bmj

A20-mediated KEAP1 ubiquitination orchestrates hepatocyte ferroptosis to ameliorate autoimmune hepatitis

Background Autoimmune hepatitis (AIH) is characterised by death of hepatocytes and chronic inflammation. Patients with deleterious variants in A20 are identified with AIH presentations and immune ...
gut.bmj

Peginterferon alpha-2a add-on to siRNA JNJ-73763989 in untreated patients with HBeAg-positive chronic hepatitis B virus (HBV) infection: the phase 2 REEF-IT study

Background In the hepatitis B e antigen positive (HBeAg+) chronic infection disease phase, approved treatments have limited effects on hepatitis B surface antigen (HBsAg) and HBeAg. Objective The ...
gut.bmj

Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit

Objective To describe the patient characteristics, diagnoses and clinical outcomes of patients presenting with acute upper gastrointestinal bleeding (AUGIB) in the 2007 UK Audit. Design Multi-centre ...
gut.bmj

Inflammatory bowel disease linked to accelerated cognitive decline in individuals with dementia: a nationwide cohort study

A recent study by Erkert et al identified a new role for Alzheimer’s disease (AD)-associated presenilins as key molecules involved in maintaining intestinal epithelial function, barrier integrity and ...
gut.bmj

Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification

Dr L Lundell, Department of Surgery, Sahlgrenska University Hospital, S-413 45 Göteborg, Sweden. BACKGROUND Endoscopic oesophageal changes are diagnostically helpful and identify patients exposed to ...
gut.bmj

Statin use association with all-cause mortality and liver-related outcomes: are the benefits true?

Zhou and colleagues published an observational study on the beneficial effects of statin use in steatotic liver disease.1 Using a large, multicentre database, the author reported that statin use in ...
gut.bmj

Combination of carvedilol with variceal band ligation in prevention of first variceal bleed in Child-Turcotte-Pugh B and C cirrhosis with high-risk oesophageal varices: the ...

Correspondence to Professor Shiv Kumar Sarin, Hepatology, Institute of Liver and Biliary Sciences, New Delhi, Delhi 110070, India; shivsarin{at}gmail.com Objectives Beta-blockers and endoscopic ...
gut.bmj

Marker antibody expression stratifies Crohn's disease into immunologically homogeneous subgroups with distinct clinical characteristics

a Department of Medicine, Cedars-Sinai Medical Center and the UCLA School of Medicine, Los Angeles, CA 90048, USA, b Department of Pediatrics, Cedars-Sinai Medical Center and the UCLA School of ...