BMJ

Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke

2 Department of Medicine, Rheumatology Unit, Karolinska Institutet/Karolinska Hospital, Stockholm, Sweden 3 Unit of Clinical Immunology, Uppsala University/Akademiska Sjukhuset, Uppsala, Sweden 4 ...
BMJ

Development of the ASQoL: a quality of life instrument specific to ankylosing spondylitis

Background: Although disease-specific health status measures are available for ankylosing spondylitis (AS), no instrument exists for assessing quality of life (QoL) in the condition. Objective: To ...
BMJ

How to diagnose axial spondyloarthritis early

Background: Chronic low back pain (LBP), the leading symptom of ankylosing spondylitis (AS) and undifferentiated axial spondyloarthritis (SpA), precedes the development of radiographic sacroiliitis, ...
BMJ

Dactylitis in psoriatic arthritis: a marker for disease severity?

1 The Psoriatic Arthritis Program, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada 2 University of Toronto ...
BMJ

Systemic lupus erythematosus (SLE) in childhood: analysis of clinical and immunological findings in 34 patients and comparison with SLE characteristics in adults

a Systemic Autoimmune Diseases Unit, Department of Medicine, IDIBAPS , Hospital Clínic, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain, * b Department of Internal Medicine, ...
BMJ

Complement activation in patients with primary antiphospholipid syndrome

Department of Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan Dr T Atsumi, Department of Medicine II, Hokkaido University Graduate School of Medicine, N15 W7, Kita-ku, ...
BMJ

The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 ...

Background: MMP-13 is one of the most important metalloproteases (MMP) involved in osteoarthritis. Licofelone, a novel dual inhibitor of cyclo-oxygenases (COX) and 5-lipoxygenase (5-LOX), can modulate ...
BMJ

Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide

Introduction: Potential hepatotoxicity associated with disease-modifying antirheumatic drugs (DMARDs) requires laboratory monitoring. In patients with rheumatoid arthritis (RA) or psoriatic arthritis ...
BMJ

Leflunomide: mode of action in the treatment of rheumatoid arthritis

a Academic Ziekenhuis Leiden, Stafcentrum Reumatologie, Leiden, The Netherlands, b Division of Immunology and Allergy, Geneva University Hospital, Geneva, Switzerland Professor F C Breedveld, Academic ...
BMJ

Osteoarthritis research priorities: a report from a EULAR ad hoc expert committee

3 Department of Internal Medicine 3, Rheumatology and Immunology, University of Erlangen-Nuremberg, Erlangen, Germany 4 Department of Rheumatology & Clinical Immunology, University Medical Center ...
BMJ

Efficacy and safety of ustekinumab in psoriatic arthritis patients with peripheral arthritis and physician-reported spondylitis: post-hoc analyses from two phase III ...

Objective To evaluate ustekinumab efficacy and safety in psoriatic arthritis (PsA) patients with peripheral arthritis and physician-reported spondylitis (termed the ‘spondylitis subset’). Methods ...
BMJ

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis

6 Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center, Ghent University, Belgium Background Dysbiosis has been recently demonstrated in patients with ankylosing ...