The largest NSAID analysis to dateone that is reportedly bigger than all other studies combinedmaps out odds ratios for MI of various products. The findings call into question the "media hysteria ...

DR. JANET WOODCOCK: Right. There are members of the NSAID class over-the-counter, and they're indicated for short-term use, for pain usually, or fever, things like ibuprofen or naproxen.

The risk climbs even for patients with diabetes lacking a history of heart failure; yet NSAIDs in such cases are prescribed surprisingly often, an observational study suggests.

People often use the wrong painkiller or take too much too quickly, increasing the risk of side effects, say pharmacists. Here are safer and more effective ways to take drugs like Advil and Tylenol.

Since receiving approval for Peluby Tablets, an NSAIDs class analgesic for osteoarthritis, in 2007, the company has been focusing on this market for 18 years.