San Francisco 49ers running back Christian McCaffrey was activated off injured reserve on Saturday and is set to make his NFL season debut on Sunday when the Niners play in Tampa Bay against the Buccaneers.

We have four teams on bye and a Sunday morning Germany game this week, lightening the main slate injury report to a certain degree. However, there are some very big names both coming and going, including one of the league's top quarterbacks likely heading for season-ending surgery and a top-flight running back expected to make his long-awaited season debut.