A newly published study in Genes & Diseases highlights the crucial role of the mammalian target of rapamycin (mTOR) pathway in the progression of diabetic nephropathy (DN) and explores its potential ...

University of Oxford-led research finds low-dose rapamycin functions as a genomic protector in aging human immune cells, ...

Tongguang Wang, Marie Medynets, Kory R. Johnson, Tara T. Doucet-O’Hare, Brianna DiSanza, Wenxue Li, Yadi Xu, Anna Bagnell, Richa Tyagi, Kevon Sampson, Nasir Malik ...

Sirolimus may be an effective treatment for patients with persistent cutaneous sarcoidosis. In a small clinical trial, 7 of 10 patients treated with sirolimus via oral solution had improvements in ...

Less than 5% of GI stromal tumors (GISTs) are driven by the loss of the succinate dehydrogenase (SDH) complex, resulting in a pervasive DNA hypermethylation pattern that leads to unique clinical ...