In many applications, interest focuses on assessing the relationship between a predictor and a multivariate outcome variable, and there may be prior knowledge about the shape of the regression curves.

We describe and contrast several different bootstrap procedures for penalized spline smoothers. The bootstrap methods considered are variations on existing methods, developed under two different ...

Single nucleotide polymorphism (SNP) interaction plays a critical role for complex diseases. The primary limitation of logistic regressions (LR) in testing SNP–SNP interactions is that coefficient ...

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