Week 4 of the NFL season is here for the New Orleans Saints, as they are set to take on one of the league's most prolific teams as they head to Highmark Stadium to battle the Buffalo Bills. This is no doubt going to be a tough matchup for the Saints to gain traction in,

The Bills committed 11 penalties but pulled away in the fourth quarter to beat the Saints. Here are the highlights.

Watch highlights of New Orleans Saints kicker Blake Grupe drilling the 54-yard field goal to make the score 14-10 vs. the Buffalo Bills in Week 4 of the 2025 NFL.

Allen was sacked by Bryan Bresee on a fruitless drive, though a roughing the kicker penalty against Nephi Sewell on the Bills’ punt killed dreams of a Saints comeback. More clock ran off before a Buffalo field goal put the lead at 31-19 just before the two-minute warning.

Spencer Rattler will make his third consecutive start at quarterback to begin the season for the Saints (0-2). Sam Darnold, who threw a pair of interceptions in a win over the Steelers last week, will be behind center for the Seahawks.

The New Orleans Saints put up a good fight, but too many critical shortcomings led to a frustrating defeat to the Buffalo Bills and an 0-4 start:

This year’s MVP frontrunner could put up some big numbers against one of the NFL’s worst teams in Week 4. Josh Allen and the Buffalo Bills are set to host the N

Check out the game action photos from the New Orleans Saints game against the Buffalo Bills for Week 4 of the 2025 NFL Season on Sept. 28, 2025 at Highmark Stadium.

Another home game at Highmark Stadium is on the horizon as the undefeated Buffalo Bills play host to the winless New Orleans Saints. Though the records show that the Saints don’t typically lose in Buffalo, if we were betting people, we’d probably throw all of our money on the Bills.

Hitting on an exact NFL score prediction could also result in a huge payday of around 100-1. How should approach a matchup of unbeatens in Eagles vs. Buccaneers (+3.5), Jaxson Dart's first start in Giants vs.