Arthur Kornberg compared DNA to a tape recording of instructions that can be copied over and over. How do cells make these near-perfect copies, and does the process ever vary? In reality, the process ...
Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...
Parvoviruses are very small (between 18 and 25 nm in diameter), non-enveloped, single-stranded DNA viruses with an icosahedral capsid. DNA replication of these viruses occurs in the nucleus, and some ...
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Uncovering the principle by which DNA replication initiation sites are determined in the human genome
When cells proliferate, genomic DNA is precisely duplicated once per cell cycle. Abnormalities in this DNA replication process can cause alterations in genomic DNA, promoting cellular aging, cancer, ...
Unlike nuclear DNA, mitochondrial DNA (mtDNA) is circular in nature and organized as mitochondrial nucleoids comprised of DNA-protein complexes that are distributed in the matrix. It is also inherited ...
A group of scientists, including Sergey Frolov, professor of physics at the University of Pittsburgh, and co-authors from Minnesota and Grenoble have undertaken several replication studies centered ...
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