G protein–coupled receptors (GPCRs) play crucial roles in the regulation of a wide variety of physiological processes and represent one-third of targets with clinically prescribed drugs. Yet, it ...

The 19 Wnt proteins found in humans are part of a larger superfamily of proteins that are also found in Archaea and Bacteria.

During lactation, the mammary gland undergoes significant structural and functional changes to produce milk, which is ...

Immune-mediated inflammatory diseases (IMIDs) are a heterogeneous group of diseases characterized by chronic inflammation and organ damage. IMIDs were traditionally classified on the basis of the ...

Yujun Wu, Yang Gao, Yanyan Zhan, Hong Kui, Hongyan Liu, Li Yan, Birgit Kemmerling, Jian-Min Zhou, Kai He, Jia Li Proceedings of the National Academy of Sciences of the United States of America, Vol.

The challenge of managing relapsed or refractory B-cell malignancies continues to thwart the efforts of oncologists and ...

Expert Rev Mol Diagn. 2009;9(2):139-156. Diagnosis AIH-score > 15 AMA-M2 Elevated aP/γ-GT Compatible histology Cholangiography Elevated aP/γ-GT pANCA IBD γ-GT = γ-glutamyl transferase; AIH = ...

Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in the early defenses against foreign cells, as well as autologous cells undergoing various forms of stress, ...

In small cell lung cancer (SCLC), the protein DLL3 is a promising target in the development of emerging therapies. In particular, DLL3-targeted therapies have been integral in ant ...

Researchers have uncovered an unusual protein activity in rice that can be exploited to give crops an edge in the evolutionary arms race against rice blast disease, a major threat to rice production ...