G protein–coupled receptors (GPCRs) play crucial roles in the regulation of a wide variety of physiological processes and represent one-third of targets with clinically prescribed drugs. Yet, it ...

During lactation, the mammary gland undergoes significant structural and functional changes to produce milk, which is ...

The 19 Wnt proteins found in humans are part of a larger superfamily of proteins that are also found in Archaea and Bacteria.

The challenge of managing relapsed or refractory B-cell malignancies continues to thwart the efforts of oncologists and ...

Yujun Wu, Yang Gao, Yanyan Zhan, Hong Kui, Hongyan Liu, Li Yan, Birgit Kemmerling, Jian-Min Zhou, Kai He, Jia Li Proceedings of the National Academy of Sciences of the United States of America, Vol.

Receptor tyrosine kinases (RTKs) regulate many critical biological processes such as cell growth, differentiation, and survival through the recruitment of intracellular signaling molecules. The ...

Immune-mediated inflammatory diseases (IMIDs) are a heterogeneous group of diseases characterized by chronic inflammation and organ damage. IMIDs were traditionally classified on the basis of the ...

Expert Rev Mol Diagn. 2009;9(2):139-156. Diagnosis AIH-score > 15 AMA-M2 Elevated aP/γ-GT Compatible histology Cholangiography Elevated aP/γ-GT pANCA IBD γ-GT = γ-glutamyl transferase; AIH = ...

Research teams explore the activation of plant immune receptors by pathogens. In a recent study, Alexander von Humboldt Professor Jijie Chai at the University of Cologne and his team together with ...

Researchers have uncovered an unusual protein activity in rice that can be exploited to give crops an edge in the evolutionary arms race against rice blast disease, a major threat to rice production ...