One way they do this is to use a DNA microarray to determine the expression levels of genes. When a gene is expressed in a cell, it generates messenger RNA (mRNA). Overexpressed genes generate ...

Upstream considerations: microarray technology The principle of a microarray experiment, as opposed to the classical northern-blotting analysis, is that mRNA from a given cell line or tissue is ...

Courtesy of CombiMatrix The research community's rapid acceptance of microarrays notwithstanding, technical challenges remain. Biochip developers continue to grapple with these issues while upgrading ...

Microarray assays can measure the transcriptional ... Also independent of prior knowledge, principle components analysis (PCA) reduces a data set with many variables to a smaller number of new ...

Expert Rev Mol Diagn. 2013;13(6):601-611. In other situations, normal microarray analysis in the presence of an abnormal karyotype, such as marker chromosomes, is reassuring, as it indicates that ...