Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.

What's the Arizona Cardinals vs San Francisco 49ers score? Follow our live score updates for latest news, highlights, analysis from NFL Week 11 game.

Setting NFL records is cool - but winning is much cooler in the eyes of Arizona Cardinals QB Jacoby Brissett. In the process of being routed by the San Francisco 49ers in Week 11, Brissett set an NFL record with 47 pass completions today.

The Arizona Cardinals have 18 players on various injured lists, the most in the NFL. The issue is especially notable with their recent draft picks.

The Arizona Cardinals quarterback, who is filling in for the injured Kyler Murray, completed 47 of his 57 pass attempts, setting a new record for completions in a single game. Drew Bledsoe had 45 completions in 1994, and Jared Goff had the same mark in 2019.

Noise surrounding the Arizona Cardinals' future with Kyler Murray will only grow louder as we creep towards the end of the 2025 regular season. Murray, who will have completed his seventh season in the league when the dust settles on the schedule, has by all expectations played his final snap for the Cardinals.