A new mass spectrometry technique captures molecules of lower abundance in a sample, providing a more comprehensive sample ...

In this collection we highlight a wide range of spatial imaging and spatial omics approaches that enable the spatial visualization of molecular targets in biological tissue. The protocols span between ...

This video shows in detail how SCiLS Lab and QuPath can be used to create regional annotations on histological images from tissue sections and tissue microarrays, and how these are integrated with ...

An international team of researchers from the University of California, Los Angeles (UCLA), Vanderbilt University, and Delft University of Technology has developed an artificial intelligence (AI) ...

Technological advances in mass spectrometry are aiding researchers to image and characterize protein and other cellular components with increasing resolution. Using native ambient mass spectrometry ...

A new tissue expansion method enables scientists to use mass spectrometry imaging to simultaneously detect hundreds of molecules at the single cell level in their native locations. For biologists, ...

For biologists, seeing is believing. But sometimes biologists have a hard time seeing. One particularly vexing challenge is seeing all the molecules in an intact tissue sample, down to the level of ...

A dedicated bioimaging function at GSK has shown how integrated microscopy and analytics can deliver quantitative evidence across drug discovery, with a particular focus on complex therapeutic ...

MALDI remains a powerful tool for analyzing large biomolecules with minimal fragmentation. In this process, peptides or proteins are co-crystallized with a matrix on a metal plate. A laser pulse ...