Mass spectrometry imaging is a powerful tool for directly determining the distribution of proteins, peptides, lipids, neurotransmitters, metabolites and drugs in neural tissue sections in situ.

Mass spectrometry imaging (MSI) technology has existed in simple form for decades, but recent advances in MS sensitivity and data analysis means it’s finally coming of age. 1 In this article, we ...

Although TOF has long been the mass spectrometry technique of choice for tissue imaging, this method is only capable of performing MS or MS 2 detection. Through the application of MALDI and linear ...

Researchers have now improved mass spectrometry imaging in such a way that the distribution of molecules can also be visualized on rippled, hairy, bulgy or coarse surfaces. The source of the laser ...

Tuesday, November 26, 2024. News & Perspective ...

Typically, mass spectrometry imaging works by scanning across a surface, and taking a mass spectrum at each spot, to build up the pixels of the image. In this case, however, the whole surface is ...

For roughly 400 years, microscopes have allowed us to observe increasingly smaller details. Today's most advanced instruments ...

Computational method provides faster high-resolution mass spectrometry imaging. Dec 10, 2020. New technique captures unprecedented view of the active brain. Mar 23, 2023.

Sidebar Key Issues. Single-cell MALDI mass spectrometry (MS) imaging resolution is currently limited by the size of laser spot diameter, matrix crystal size/homogeneity, displacement of analytes ...