Time, TV Channel and Live Stream – 2025 Week 4
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San Francisco is a 3.5-point favorite in the latest Jaguars vs. 49ers odds from SportsLine consensus, while the over/under for total points scored is 45.5. The 49ers are -175 money line favorites (risk $175 to win $100),
AFC South squads face off looking for their first win on Sunday, Sept. 28 when the Houston Texans host the Tennessee Titans.