New research shows that curium — one of the heaviest known elements — can be manipulated to a larger degree than previously thought. An international team published a study on July 15 in the journal ...

Researchers found that an increased inactivation efficiency rate was linked to greater drug potency, but only to a certain point. Eventually, as the TCIs worked faster, their potency plateaued and the ...

Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...

One of the key challenges in chemistry is to break and form bonds selectively in complex organic molecules that possess a range of different functional groups. To do this at the single-molecule level ...

Matchpoint Therapeutics has publicly launched with $70 million in series A financing and an earlier $30 million in seed money to develop covalent drugs for immune diseases. Its founders include ...

Experimental evidence has confirmed earlier computational studies showing that the Au–C bonds in Au(CN) 2-have significant covalent character, in contrast to the ionic behavior of gold's lighter ...

One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs). These small molecule drugs form covalent bonds with their ...