The serine 31 (Ser31) phosphorylation modification (H3.3S31ph) in the N-terminal tail of the histone variant H3.3 can ...

Histones are among the most abundant proteins in the body. They act as spools that help compact DNA so our enormous genomes will fit in the tight space of the nucleus. Each spool is made of eight ...

A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA transcription into RNA – the first step of the process by which an organism's ...

Genomic DNA is wrapped around histone octamers to provide nucleosomes that are further compacted in chromatin fibers. To up-regulate a gene (a), the activator binds to a specific sequence and recruits ...

Our group has contributed to the molecular and functional understanding of histone mark and DNA methylation mark readout by writer, reader and eraser proteins, as well as investigated the crosstalk ...

In a recent study published in the journal Science Advances, a group of researchers investigated the role of histone modifications in human aging by developing and evaluating histone-specific age ...

ITHACA, N.Y. -- A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA transcription into RNA – the first step of the process by which ...

UNIVERSITY PARK, Pa. — New research provides insight into how an enzyme that helps regulate aging and other metabolic processes accesses our genetic material to modulate gene expression within the ...

Discover how histone modifications unlock secrets of human aging, rivaling the precision of DNA methylation in decoding biological age. In a recent study published in the journal Science Advances, a ...