Basement membranes are extracellular matrices—flat sheets of protein and carbohydrate—that are essential for tissue architecture and function. But like all tissues, they are subject to damage. Until ...

Researchers created a DIA-MS atlas of 13,609 proteins across 2,856 samples from fetal, healthy adult, paired non-tumor, and ...

Reactive oxygen species (ROS) produced naturally during cellular metabolism often cause oxidative damage to cells. However, these molecules also play an important role in normal cellular signaling.

Structural anisotropy is a hallmark of many tissues in humans. The spatially aligned organization of cells and extracellular matrix (ECM) is crucial to physiological functions such as contraction ...

Our bodies are constantly breaking down. Over time, their built-in repair mechanisms also fail. Knee cartilage grinds away. Hip joints no longer support weight. Treatments for breast cancer and other ...

Researchers at Hospital for Special Surgery (HSS) have uncovered a critical link between the immune system in early life and ...

Biomedical engineers from the University of Melbourne have invented a 3D printing system, or bioprinter, capable of fabricating structures that closely mimic the diverse tissues in the human body, ...

Aging affects every organ in the body, yet we still know little about how the ovary changes over time. In a new study published in Nature Aging, Yale researchers created one of the most detailed maps ...

The fat tail of sheep is an important organ that has evolved to adapt to extreme environments. However, the genetic mechanisms underlying the fat tail phenotype remain poorly understood. Here, we ...