Endotoxin refers to a component of the outer cell membrane of Gram-negative bacteria called lipopolysaccharide (LPS). LPS is the biologically active portion of naturally occurring endotoxin complexes.

This article serves as your comprehensive guide to endotoxin testing—covering key principles, methods, and best practices.

Regulatory changes may make the pharmaceutical industry less reliant on horseshoe crabs for quality assurance testing. Credit: Courtesy of Tim Cernak At a recent meeting of the Parenteral Drug ...

Jai Prakash (left) is a Professor in the Department of Advanced Organ Bioengineering and Therapeutics at the University of Twente (Enschede, Netherlands), where he works with Postdoc Marcel Heinrich ...

The biologic effects of endotoxin are attributed to the release of several cytokines, including interleukin-1, interleukin-6, tumor necrosis factor, and the colony-stimulating factors. To investigate ...

Now Niederweis and colleagues at the University of Alabama at Birmingham describe the mechanism of secretion and trafficking of that toxin, TNT, which is the major cytotoxicity factor for the pathogen ...

Sino Biological US, Inc. proudly unveils ProPure™, an industry-leading line of ultra-pure, endotoxin-free recombinant proteins, fully produced in the USA at its state-of-the-art Center for ...

Charles River International Laboratories, Inc. CRL recently launched Endosafe Trillium rCR cartridges, which combine its hallmark Endosafe cartridge technology with recombinant cascade reagent (rCR).

In this episode of C&EN Uncovered, host Craig Bettenhausen speaks with C&EN assistant editor Laurel Oldach about the use of horseshoe crab blood in pharmaceutical endotoxin testing, the challenges of ...