Sox9, a master regulator of cartilage formation, switches its target genes dynamically during embryonic limb development instead of following a fixed program, as reported by researchers from Science ...

Studying the shape of tissues and organs is critical to understanding how they are formed. Embryonic development happens in three dimensions, but many studies are limited by the use of two-dimensional ...

Scientists at EPFL have created a scalable 3D organoid model that captures key features of early limb development, revealing how a specialized signaling center shapes both cell identity and tissue ...

Limb progenitor cells then bud out where a limb will form and provide a framework for the future arm, leg, wing, or fin. "We've found the proteins that imbue 'limbness' to this subgroup of mesenchymal ...

The experimental analysis of chick limb bud development / J.W. Saunders Jr. -- In-vitro analysis of the distribution and nature of a morphogenetic factor in the developing chick wing / J.A. MacCabe, A ...