The Chicago Cubs will try to avoid a two-game sweep in the opening series of the MLB season on Wednesday. First pitch against the Los Angeles Dodgers will be at 6:10 a.m. ET. The defending World Series champions won the 2025 opener on Tuesday, 4-1.

The Chicago Cubs took on on the Los Angeles Dodgers in Tokyo early Tuesday morning in the first of a two-game set to kick off the regular season, a game which ended in a 4-1 loss for the Cubs. Though Chicago struck first in the bottom of the second inning with a huge double from Miguel Amaya to bring Dansby Swanson to the plate,

The Los Angeles Dodgers will seek to take the second of two games from the Chicago Cubs to open the MLB season on Wednesday. First pitch is scheduled for 3:10 a.m. PT. Los Angeles won the first matchup on Tuesday, 4-1.