The NFL season continues in Week 11 when the San Francisco 49ers host the Arizona Cardinals on Sunday. Start time, how to watch, streaming and NFL schedule.

Setting NFL records is cool - but winning is much cooler in the eyes of Arizona Cardinals QB Jacoby Brissett. In the process of being routed by the San Francisco 49ers in Week 11, Brissett set an NFL record with 47 pass completions today. Brissett, when speaking with reporters after the loss, says he couldn't care less.

Kickoff from State Farm Stadium is set for 4:25 p.m. ET on FOX. The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.

The San Francisco 49ers face the Arizona Cardinals in Week 11 of the NFL season on Sunday at State Farm Stadium.

Brissett completed 47 passes in Arizona's 41-22 loss to the San Francisco 49ers at State Farm Stadium to etch his name in the NFL record books for most completions in a regular-season game. He also produced a career-high 452 passing yards.

The Arizona Cardinals have 18 players on various injured lists, the most in the NFL. The issue is especially notable with their recent draft picks.

Noise surrounding the Arizona Cardinals' future with Kyler Murray will only grow louder as we creep towards the end of the 2025 regular season. Murray, who will have completed his seventh season in the league when the dust settles on the schedule, has by all expectations played his final snap for the Cardinals.

The Arizona Cardinals quarterback, who is filling in for the injured Kyler Murray, completed 47 of his 57 pass attempts, setting a new record for completions in a single game. Drew Bledsoe had 45 completions in 1994, and Jared Goff had the same mark in 2019.

With the activation of linebacker BJ Ojulari from PUP Saturday and the addition of linebacker Mack Wilson Sr. to IR, the Cardinals now have 13 players placed on IR since the cut to 53, three on IR prior to the cut to 53 and one, cornerback Sean Murphy-Bunting, on reserve/non-football injury, also done prior to the reduction to 53.

ARIZONA -- Arizona Cardinals TE Trey McBride was flagged for an unsportsmanlike conduct penalty in their Week 11 loss to the San Francisco 49ers, a penalty that drew plenty of criticism online and around the football world. The flag came after McBride celebrated a first down.