A Science Immunology Review explains how memory B cells acquire diverse molecular, epigenetic, and tissue-specific programs ...

As of April 2025, four CD19-directed chimeric antigen receptor (CAR)-T therapies and three CD20-targeting bispecific antibodies (BsAbs) have been US Food and Drug Administration (FDA) approved for the ...

Emerging immunotherapy treatments for multiple myeloma target B-cell maturation antigen (BCMA), a protein found on the surface of cancer cells. Multiple myeloma is a blood cancer that develops when ...

Immune cells called B cells make antibodies that fight off invading bacteria, viruses and other foreign substances. During their preparation for this battle, B cells transiently revert to a more ...

B lymphocytes exhibit dual roles in tumorigenesis, acting as both allies and adversaries in the tumor microenvironment (TME). Their anti-tumor functions include recognizing tumor-associated antigens, ...