Thus, mitochondrial Hsp70 fulfills a dual function in the formation of ATP synthase: the assembly of the catalytic head and the controlled linkage of the head to the stator.

Solving the structure of ATP synthase Barrier lifted in understanding function in disease and drug mechanisms Date: April 17, 2018 Source: Rosalind Franklin University of Medicine and Science ...

The need for sleep likely evolved to get rid of toxic molecules from the mitochondria, a landmark study shows using ...

The chemical ATP, adenosine triphosphate, is the fuel that powers all life. Despite ATP's central role, the structure of the enzyme generating ATP, F1Fo-ATP synthase, in mammals, including ...

Scientists at the University of Bonn have clarified a surprising dual function of ceramide synthase. The enzyme not only catalyzes a central step of the production of vital lipids. It also has the ...

Regulating the flow of protons across the chloroplast and modulating the activity of its CFo-CF1 adenosine triphosphate (ATP) synthase protein are key to protecting plants from excessive light energy ...

Mechanistically, these muropeptides were shown to enter intestinal-cell mitochondria to interact with the F1 complex of ATP synthase, stabilizing the complex and increasing mitochondrial respiration.

Naoki Soga, Kazuya Kimura, Kazuhiko Kinosita Jr., Masasuke Yoshida, Toshiharu Suzuki, Perfect chemomechanical coupling of FₒF₁-ATP synthase, Proceedings of the National Academy of Sciences of the ...

With no known treatments for mitochondrial diseases or ATP synthase deficiency, the use of muropeptides as an ATP agonist is a significant discovery.