An interesting feature of antisense oligonucleotides (ASOs) is their unrivaled specificity for their drug targets, underpinned by the precise Watson-Crick base pairing rule. ASOs are programmed to ...

The ability to make synthetic DNA and RNA by chemical or enzymatic means has revolutionized genetic research and drug discovery. Antisense technology employs short, chemically synthesized ...

UCSC researchers will synthesize the top ASO designs proposed by Eterna players and test them in laboratory experiments. The UCSC team includes Victor Tse (above), a graduate student in MCD Biology.

When the drug fomivirsen was approved by the FDA in 1998 for the treatment of cytomegalovirus retinitis in patients with HIV/AIDs, it was hailed as a milestone in drug discovery because it was the ...

Phosphorothioate (PS)-modified antisense oligonucleotides (ASOs) are widely used to modulate gene expression in basic research and therapy. Within cells, these ASOs seed nuclear structures with ...

A promising therapy for a range of brain diseases involves antisense oligonucleotides (ASOs) - specialized molecules that can modulate RNA and alter protein production - directly injected into the ...

BOSTON - Dr. Tim Yu refers to the letters of the genetic code as Lego blocks. His lab at Boston Children's Hospital has become known for putting the Legos together just right and using them to develop ...

Flamingo Therapeutics BV and Ionis Pharmaceuticals Inc.’s FTX-001 (also known as FLM-7523) is a potential first-in-class antisense oligonucleotide (ASO) targeting the human metastasis-associated lung ...

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of RNA-based drugs can significantly enhance their effectiveness. These ...