SANTA CLARA, Calif. (AP) — Brock Purdy returned to the lineup and the San Francisco 49ers scored their most points in nearly two years. While Purdy looked sharp in the 41-22 victory over the Arizona Cardinals on Sunday, the reasons behind the big scoring output have to do with a lot more than just the change at quarterback.

ARIZONA -- The Arizona Cardinals are no strangers to adjusting to opposing fans at State Farm Stadium, though the San Francisco 49ers tend to travel among the best in the NFL in terms of away support.

Arizona Cardinals head coach Jonathan Gannon is ignoring the hot seat rumors after Sunday's humiliating 41-22 loss to the San Francisco 49ers.

Veteran fullback Kyle Juszczyk opens up about what made the San Francisco 49ers’ 41-22 Week 11 win over the Arizona Cardinals so special for him.

The San Francisco 49ers notched a fairly impressive, and expected, win against the Arizona Cardinals. It was a nice rebound after getting throttled last week. P

Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host Cardinals (3-7).

The 49ers have their franchise quarterback back. "He was vintage Brock," Christian McCaffrey said. "That's a huge compliment."

On a 70-yard, first-quarter drive that made the score 13-0, the 49ers needed only five plays to reach the end zone with three plays gaining 13 and 25 by Demarcus Robinsion and Jauan Jennings, respectively, and a 30-yard touchdown by Kittle.

The 49ers are 3.5-point favorites, according to the latest 49ers vs. Cardinals odds. The over/under for total points scored is 48.5. Before making any 49ers vs. Cardinals picks, make sure you check out the NFL picks from the SportsLine Projection Model.