Stay up to date here with the latest news and highlights from the Indianapolis Colts' Week 16 matchup on Monday Night ...

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the ...

The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, highlights ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats ...

The San Francisco 49ers have officially put their playoff destiny in their own hands.

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high ...

Christian McCaffrey battles his former team in primetime as the 49ers face the Panthers in the Week 12 finale.

Purdy showed poise and command throughout the high-stakes game, spreading the wealth to playmakers like Christian McCaffrey and George Kittle while keeping the Colts defense guessing. The 49ers have a ...

The 49ers have arguably the toughest two-game closing stretch among the teams in playoff positions. They face the Chicago ...

The San Francisco 49ers and Cleveland Browns meet on Sunday with the visiting team chasing the playoffs in the hotly contested NFC West, while the Browns are looking to see more of Shedeur Sanders ...

The San Francisco 49ers defense struggled some against the Tennessee Titans, but their offense had a huge day to mark the ...

The Tennessee Titans are monster-sixed underdogs against the San Francisco 49ers in this Week 15 tilt. However, my Titans vs. 49ers predictions look at the total, as I see a bigger edge on the Over.