Arizona had the passing game working, but it didn't matter in a 41-22 loss to San Francisco at State Farm Stadium in Glendale.

The San Francisco 49ers notched a fairly impressive, and expected, win against the Arizona Cardinals. It was a nice rebound after getting throttled last week. P

Former Pro Bowl RB LeSean McCoy believes the Arizona Cardinals point shaved in their Week 11 loss to the San Francisco 49ers.

San Francisco 49ers tight end George Kittle (85) catches a touchdown pass in front of Arizona Cardinals linebacker Akeem Davis-Gaither (27) during the first half of an NFL football game in Glendale, Ariz., Sunday, Nov. 16, 2025. Credit: AP/Ross D. Franklin

San Francisco 49ers tight end George Kittle (85) celebrates his touchdown catch with teammates Jake Tonges (88) and Kendrick Bourne (84) during their game against the Arizona Cardinals at State Farm Stadium in Glendale on Nov. 16, 2025. / Joe Rondone/The Republic / USA TODAY NETWORK via Imagn Images

The 49ers' team captains stepped up in Arizona. One of them, George Kittle, said the team is positioned right where it needs to be.

Preview the Week 11 matchup between the San Francisco 49ers and Arizona Cardinals with predictions, odds, over/under, spread, betting lines and more.

ARIZONA -- The Arizona Cardinals are no strangers to adjusting to opposing fans at State Farm Stadium, though the San Francisco 49ers tend to travel among the best in the NFL in terms of away support.