In Week 3, running back Isaac Guerendo and the San Francisco 49ers' rushing attack will square off against the Los Angeles Rams and their 30th-ranked run defense (197 rushing yards allowed per game). The game has a kickoff time of 4:25 PM ET on Sunday.

Sunday's game between the Los Angeles Rams and San Francisco 49ers is a big one for both teams. The Rams are trying to avoid a dreaded 0-3 start, while the 49ers are trying to move above .500 rather than sinking to 1-2.

Everyone knows how badly the Rams have struggled against the 49ers over the last five years, dropping nine of their last 10 regular-season meetings. But they can change the narrative a bit with an upset win over San Francisco on Sunday afternoon.

The San Francisco 49ers will be missing two of their biggest playmakers when they visit SoFi Stadium on Sunday to face the Los Angeles Rams. Running

After their offense went stagnant in Week 2 without one of their star performers, the San Francisco 49ers will look to recover Sunday when they visit their home away from

The Los Angeles Rams are facing a tumultuous beginning to their 2024 NFL season, standing at an unfortunate 0-2 record. This marks the first time under head coach Sean McVay that the team has opened a season this poorly.

The Los Angeles Rams signed former Wisconsin wide receiver Quintez Cephus to their practice squad on Wednesday, per ESPN’s Adam Schefter. Cephus’ acquisition is somewhat notable considering the Rams’ recent wide receiver woes. All-world pass-catcher Cooper Kupp (ankle) and 2023 rookie sensation Puka Nacua (knee) are projected to miss extended time.