Grand Bay is an unincorporated community and census-designated place in Mobile County, Alabama, United States. It is part of the Mobile metropolitan area. The population was 3,460 at the 2020 census. According to local accounts, George Cassibry was the first white person to settle in Grand Bay. He came to the area in 1853, establishing a hom…Grand Bay is an unincorporated community and census-designated place in Mobile County, Alabama, United States. It is part of the Mobile metropolitan area. The population was 3,460 at the 2020 census. According to local accounts, George Cassibry was the first white person to settle in Grand Bay. He came to the area in 1853, establishing a home site near the headwaters of Franklin Creek located today near the intersection of Highway 90 and Ramsey Road. Exploration and settlement of the area was well underway by the mid-nineteenth century.