Greenville is a city located on U.S. Route 67 near the intersection with Route D and E in Wayne County, Missouri, United States, along the St. Francis River. The population was 443 at the 2020 census. Greenville was incorporated and founded as the county seat of Wayne County in 1819.
AdFind Your Perfect Somewhere on Hotels.com. Check Out Our Amazing Deals. Take Advantage of Low Rates on Hundreds of Thousands of Top-Rated Hotels. Book Now!