Alzheimer's: Boosting brain protein may slow cognitive decline
WEB2 days ago · Share on Pinterest New research looks into the role of amyloid-beta in developing Alzheimer’s. Westend61/Getty Images A main theory behind the cause of Alzheimer’s disease is the build-up of ...
In breakthrough Alzheimer's discovery, research team ... - ScienceDaily
WEBIn breakthrough Alzheimer's discovery, research team finds new targets and biomarkers for potential novel therapies. Scientists explain how the amyloid beta deposits long known to build up in...
New Treatment Reverses Alzheimer’s Disease Signs
WEBDec 20, 2023 · Both early-life and middle-age treatment showed signs of inhibiting the process that forms the most prominent protein aggregates in Alzheimer’s, known as amyloid beta plaques. For the later treatment, not only the underlying process but also the amyloid plaque numbers themselves were reduced.
Understanding changes in pre-clinical Alzheimer's disease: Study …
WEB1 day ago · Amyloid-beta and tau proteins have long been associated with Alzheimer's disease. The pathological buildup of these proteins leads to cognitive decline in people with the disease. How it does that ...
Immune cells key in blood vessel damage, neurodegeneration
WEB1 day ago · This triggers a chain reaction that damages blood vessels, preventing them from clearing amyloid, which leads to degeneration of brain tissue. In their latest study, the researchers show that pre-clinical models genetically engineered to express the human ApoE4 variant developed impaired blood vessels and tissue damage in their brains, while ...
The amyloid hypothesis in Alzheimer disease: new insights from …
WEBFeb 17, 2022 · Soluble oligomeric Aβ and deposited Aβ in amyloid plaques interact with microglia, astroglia, blood vessels and neurons to induce various damaging cellular responses that ultimately lead to...
Immune cells linked to blood vessel damage and neurodegeneration
WEB7 hours ago · For now, they are looking for ways to block the receptors that mediate ApoE4-related blood vessel damage to reduce or prevent the genetic variant's harmful effects on the amyloid-beta clearance ...
New culprit in amyloid beta buildup, neurodegeneration
WEBNov 8, 2023 · Researchers at Weill Cornell Medicine have demonstrated how amyloid beta, a peptide associated with Alzheimer’s disease, can interact with a protein receptor on immune cells in the brain. This triggers a reaction that damages blood vessels and causes neurodegeneration.
Two Phase 3 Trials of Gantenerumab in Early Alzheimer’s Disease
WEBNov 15, 2023 · Monoclonal antibodies that target amyloid-beta (Aβ) have the potential to slow cognitive and functional decline in persons with early Alzheimer’s disease.
The Amyloid-β Pathway in Alzheimer’s Disease - Nature
WEBAug 30, 2021 · Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the center of Alzheimer’s disease (AD) pathophysiology.
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